In recent days, we had the opportunity to conduct numerous tests of our prototype 3D bioprinter solution, BioCloner Desktop, at the E.J. Brzeziński Biomedical Engineering Laboratory at the Warsaw University of Technology (Faculty of Mechanical and Technological Engineering). The work was carried out under conditions of elevated cleanliness in a laminar chamber. We had the opportunity to work with biomaterials supplied by BIO INX® - EASYGEL INX© and Polbionica - methacrylated gelatin TINTBIONICTM GELMA80 LAP, which underwent prior lyophilization to obtain a hydrogel.

Both of these materials are photosensitive, allowing us to test our dedicated solutions for working with such biomaterials. To obtain scaffolds, we used our custom printing head, which allowed us to conduct the process while controlling the temperature of the extruded material and providing continuous or point-wise UV exposure. The constant control of working conditions and the process resulted in obtaining pre-planned scaffolds, which were later used by scientists from the Warsaw University of Technology in the cell colonization process. Work on cell cultures in the space of printed scaffolds was possible by adapting the 3D bioprinting protocol to standardized laboratory equipment. Each print was conducted in the volume of a single cell of a microscopic slide with dimensions of 0.5 cm x 1.5 cm.

It was an incredibly fruitful time, both scientifically and business-wise, which resulted in the development of work protocols with commercial materials based on methacrylated gelatin with the addition of photoinitiators. This approach fits perfectly with the product philosophy of our activity because we want to provide a bioprinter that can easily cooperate with independently prepared biomaterials as well as those already present on the market.

The tests provided us with significant information regarding the correct parameters for working with the aforementioned materials. These results will be used to create predefined protocols embedded in our machine.

We are aware that there are still many tests and work ahead of us. Both our solutions and the team are constantly evolving and working to adapt to industry requirements. Soon, there will be more tests, more biomaterials, and inspiring projects from us and our partners. 

BioCloner 3D is heading to the market!